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opinion on vitamin a (Retinol, Retinyl Acetate, Retinyl Palmitate)

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This Opinion has been subject to a commenting period of a minimum four weeks after its initial publication. Comments received during this time were considered by the SCCS and discussed in the subsequent plenary meetings. For this Opinion, comments received resulted in the following changes that have been adopted on 23 December 2016 by written procedure: Chapter 3.2 Function and uses, SCCS general conclusion on the repeated dose toxicity of Vitamin A (page 51), chapter 3.3.7 Human data and the respectives conclusions number 2 and 3. A corrigendum on impurities on pages 11,63 and 70 as well as acknowledgments

Scientific Committee on Consumer Safety - SCCS

OPINION ON VITAMIN A

 (Retinol, Retinyl Acetate, Retinyl Palmitate)

 

This Opinion has been subject to a commenting period of a minimum four weeks after its initial publication. Comments received during this time were considered by the SCCS and discussed in the subsequent plenary meetings. For this Opinion, comments received resulted in the following changes that have been adopted on 23 December 2016 by written procedure: Chapter 3.2 Function and uses, SCCS general conclusion on the repeated dose toxicity of Vitamin A (page 51), chapter 3.3.7 Human data and the respectives conclusions number 2 and 3. A corrigendum on impurities on pages 11,63 and 70 as well as acknowledgments

 

Table of Contents

ACKNOWLEDGMENTS

1. BACKGROUND

2. TERMS OF REFERENCE

3. OPINION

3.1 Chemical and Physical Specifications

3.1.1 Chemical identity

3.1.2 Physical form

3.1.3 Molecular weight

3.1.4 Purity, composition and substance codes

3.1.5 Impurities/ accompanying contaminants

3.1.6 Solubility

3.1.7 Partition coefficient (Log Pow)

3.1.8 Additional physical and chemical specifications

3.1.9 Homogeneity and Stability

3.2 Function and uses

3.3 Toxicological Evaluation

3.3.1 Acute toxicity

3.3.2 Irritation and corrosivity

3.3.3 Skin sensitisation

3.3.3 Dermal/ percutaneous absorption

3.3.4 Repeated dose toxicity

3.3.5 Toxicokinetics

3.3.6 Photo-induced toxicity

3.3.7 Human data

3.3.8 Special investigations

3.4 Exposure Evaluation

3.4.1 Exposure from cosmetic products

3.4.2 Exposure from other sources

3.4.3 Safety evaluation (including calculation of the MOS)

3.4.4 Discussion

4. CONCLUSION

5. MINORITY OPINION

6. REFERENCES

 

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opinion on vitamin a (Retinol, Retinyl Acetate, Retinyl Palmitate)

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